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Rabbit Anti-Calcyon/AF350 Conjugated antibody (bs-11719R-AF350)
订购热线:400-901-9800
订购邮箱:[email protected]
订购传真:010-58129612
技术支持:[email protected]
说 明 书:100ul  
100ul/2980.00元
大包装/询价
产品编号bs-11719R-AF350
英文名称Anti-Calcyon/AF350
中文名称AF350标记的多巴胺D1受体相互作用蛋白抗体
别    名CALCYON; Drd1ip; Caly; CALY_HUMAN; D1 dopamine receptor interacting protein; Drd1ip; Neuron specific vesicular protein calcyon; Neuron-specific vesicular protein calcyon; NSG3; RP11-122K13.5.  
规格价格100ul/2980元购买        大包装/询价
说 明 书100ul  
研究领域神经生物学  细胞膜受体  跨膜蛋白  细胞膜蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Rabbit, 
产品应用ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Calcyon (3-65aa)
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
Calcyon is a single transmembrane protein that interacts with D1 dopamine receptors. Dopamine is a neurotransmitter that regulates synaptic transmission involved in learning and memory. D1 receptors, the most abundant dopamine receptor in the central nervous system, appear to modulate the activity of D2 dopamine receptors, mediate various behavioural responses, and regulate neuron growth and differentiation. Calcyon is present in neuronal cell bodies and processes of the cortex and hippocampus, and it is especially abundant in pyramidal neurons. Interaction of Calcyon with D1 receptors results in a release of intracellular calcium.

Function:
Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.

Subunit:
nteracts with CLTA.

Subcellular Location:
Cytoplasmic vesicle membrane. Cell membrane.

Tissue Specificity:
Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.

Post-translational modifications:
Glycosylated.

Similarity:
Belongs to the NSG family.

Database links:

Entrez Gene: 50632 Human

Entrez Gene: 68566 Mouse

Entrez Gene: 192349 Rat

Omim: 604647 Human

SwissProt: Q9NYX4 Human

SwissProt: Q9DCA7 Mouse

SwissProt: P58821 Rat

Unigene: 148680 Human

Unigene: 44241 Mouse

Unigene: 27756 Rat

 

 

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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