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Rabbit Anti-Capicua/AF350 Conjugated antibody (bs-11721R-AF350)
订购热线:400-901-9800
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订购传真:010-58129612
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说 明 书:100ul  
100ul/2980.00元
大包装/询价
产品编号bs-11721R-AF350
英文名称Anti-Capicua/AF350
中文名称AF350标记的Capicua蛋白抗体
别    名Capicua homolog (Drosophila); Cic; CIC; KIAA0306; Protein capicua homolog; CIC_HUMAN.  
规格价格100ul/2980元购买        大包装/询价
说 明 书100ul  
研究领域神经生物学  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量164kDa
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Capicua (1475-1560aa)
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
Capicua is the mammalian ortholog of the drosophilia Cic gene and is part of the HMG-box protein superfamily. Expressed primarily in the fetal brain, Capicua functions as a transciptional repressor and is involved in the development of the nervous system through interaction with the ATXN1 protein. When ATXN1 assembles into stable complexes, it directly binds Capicua, thereby mediating both the activity and expression of Capicua. When Capicua is active, it is able to interact with other developmental proteins to restrict the growth of granule cells and regulate normal neuronal development. Disruptions in the the association of Capicua with proteins such as ATXN1 are thought to cause medulloblastoma, the most common form of perdiatric brain tumor arising from irregular growth of granule cells.

Function:
Transcriptional repressor which may play a role in development of the central nervous system (CNS).

Subunit:
Interacts with ATXN1 and ATXN1L

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in fetal brain.

Similarity:
Contains 1 HMG box DNA-binding domain.

Database links:

Entrez Gene: 23152 Human

SwissProt: Q96RK0 Human

Unigene: 388236 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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