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Rabbit Anti-PINX-1/AF350 Conjugated antibody (bs-9594R-AF350)
订购热线:400-901-9800
订购邮箱:[email protected]
订购传真:010-58129612
技术支持:[email protected]
说 明 书:100ul  
100ul/2980.00元
大包装/询价
产品编号bs-9594R-AF350
英文名称Anti-PINX-1/AF350
中文名称AF350标记的端粒酶抑制因子PinX-1抗体
别    名67-11-3 protein; FLJ20565; Hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTL; LPTS; MGC8850; PIN2 interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; PINX1; PINX1_HUMAN; Protein 67-11-3; TRF1-interacting protein 1.  
规格价格100ul/2980元购买        大包装/询价
说 明 书100ul  
研究领域肿瘤  细胞生物  转录调节因子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Horse, 
产品应用ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PINX-1
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
PINX1 is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains one G-patch domain and one telomeric inhibiting domain (TID) at its C-terminus. PINX1 interacts with the telomere protein TRF1 and the telomerase reverse transcriptase TERT. The TID domain of PINX1 specifically interacts with TERT and functions to inhibit its activity, thus participating in the regulation of telomerase activity. Overexpression of PINX1 leads to shortened telomeres, further supporting an inhibitory role of PINX1 on telomerase activity. The depletion of PINX1 significantly increases telomerase activity and may lead to tumorigenicity of cancer cells. This suggests that PINX1 acts as a tumor suppressor and can inhibit cell proliferation. In addition, PINX1 is involved in nucleolar RNA maturation.

Function:
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.

Subunit:
Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous; expressed at low levels.

Similarity:
Belongs to the PINX1 family.
Contains 1 G-patch domain.

Database links:

Entrez Gene: 54984 Human

Entrez Gene: 72400 Mouse

Entrez Gene: 305963 Rat

Omim: 606505 Human

SwissProt: Q548A5 Human

SwissProt: Q6QWG9 Human

SwissProt: Q96BK5 Human

SwissProt: Q9CZX5 Mouse

SwissProt: A4L691 Rat

Unigene: 490991 Human

Unigene: 583894 Human

Unigene: 379214 Mouse

Unigene: 15365 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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