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Rabbit Anti-EBF2/Cy7 Conjugated antibody (bs-11740R-Cy7)
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订购传真:010-58129612
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说 明 书:100ul  
100ul/2980.00元
大包装/询价
产品编号bs-11740R-Cy7
英文名称Anti-EBF2/Cy7
中文名称Cy7标记的早期B淋巴细胞因子2抗体
别    名COE 2; COE2; Collier Olf and EBF 2; Early B cell factor 2; EBF 2; FLJ11500; Metencephalon mesencephalnon olfactory transcription factor 1; O/E 3; O/E3; OE 3; OE3; OLF 1/EBF like 3; Transcription factor COE2; COE2_HUMAN.  
规格价格100ul/2980元购买        大包装/询价
说 明 书100ul  
研究领域细胞生物  神经生物学  转录调节因子  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量63kDa
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human EBF2 (331-400aa)
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
Early B-cell factor 2 is a 575 amino acid protein belonging to the COE family of proteins, whose members are all helix-loop-helix transcription factors. EBF2 is a transcription factor which, in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, activates the decoy receptor for RANKL, OPG, in osteoblasts. OPG, in turn, regulates osteoclast differentiation. Lack of EBF2 has been found to cause a small defect in the terminal differentiation of osteoblasts, along with reduced bone mass and an increase in osteoclasts. Localized to the nucleus, EBF2 forms a homodimer or a heterodimer with a related family member.

Function:
EBF2 (Early B-cell factor 2) belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors. In osteoblasts it activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. EBF2 acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. It recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.

Subunit:
Forms either a homodimer or a heterodimer with a relatedfamily member

Subcellular Location:
Nuclear

Similarity:
Belongs to the COE family.
Contains 1 IPT/TIG domain.

Database links:
UniProtKB/Swiss-Prot: Q9HAK2.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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